Effect of ritonavir-induced cytochrome P450 3A4 inhibition on plasma fentanyl concentrations during patient-controlled epidural labor analgesia: a pharmacokinetic simulation

Author:

Cambic C.R.,Avram M.J.,Gupta D.K.,Wong C.A.

Publisher

Elsevier BV

Subject

Anesthesiology and Pain Medicine,Obstetrics and Gynaecology

Reference22 articles.

1. Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection;Volmink;Cochrane Database Syst Rev,2007

2. Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients;Zeldin;J Antimicrob Chemother,2004

3. Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions;Labroo;Drug Metab Dispos,1997

4. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes;Kumar;J Pharmacol Exp Ther,1996

5. Ritonavir’s role in reducing fentanyl clearance and prolonging its half-life;Olkkola;Anesthesiology,1999

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