Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

Author:

William Langston J.,Forno Lysia S.,Rebert Charles S.,Irwin Ian

Publisher

Elsevier BV

Subject

Developmental Biology,Clinical Neurology,Molecular Biology,General Neuroscience

Reference7 articles.

1. A primate model of Parkinson's disease: selective destruction of substantia nigra, pars compacta dopaminergic neurons by N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine;Burns,1983

2. N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a parkinsonian syndrome causing agent in man and monkey, produces different effects in guinea pig and rat;Chiueh;Pharmacologist,1983

3. Chronic parkinsonism secondary to intravenous injection of meperidine analogues;Davis;Psychiat. Res.,1979

4. Pathology of Parkinson's Disease;Forno,1982

5. Pharmacological actions of 6-hydroxydopamine;Kostrzewa;Pharmacol. Rev.,1974

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