Substituted naphthalenones as a new structural class of HIV-1 reverse transcriptase inhibitors

Author:

Alam Masud,Bechtold Clifford M.,Patick Amy K.,Skoog Mark T.,Gant Thomas G.,Colonno Richard J.,Meyers A.I.,Li Hui,Trimble John,Lin Pin-Fang

Publisher

Elsevier BV

Subject

Virology,Pharmacology

Reference29 articles.

1. Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative;Baba;Biochem. Biophys. Res. Commun.,1989

2. Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase;Baba,1991

3. 2′,5′-Bis-O-(tert-butyldimethylsilyl)-3′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide)pyrimidine (TSAO) nucleoside analogues: Highly selective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase;Balzarini,1992

4. Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue (2′,5′-Bis -O-(tert-butyldimethylsilyl)-β-d- ribofuranosyl)-3′-spiro-5″-(4″-amino-1″,2″-oxathiole- 2″,2″-dioxide) thymine (TSAO-T);Balzarini;J. Biol. Chem.,1992

5. HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase;Balzarini;Virology,1993

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