Neurocognition and functional outcome in patients with psychotic, non-psychotic bipolar I disorder, and schizophrenia. A five-year follow-up

Author:

Jiménez-López Estela,Sánchez-Morla Eva María,López-Villarreal Ana,Aparicio Ana Isabel,Martínez-Vizcaíno Vicente,Vieta Eduard,Rodriguez-Jimenez Roberto,Santos José Luis

Abstract

AbstractBackground:Bipolar disorder (BD) and schizophrenia (SZ) are characterized by neurocognitive and functional deficits with marked heterogeneity. It has been suggested that BD with a history of psychotic symptoms (BD-P) could constitute a phenotypically homogeneous subtype characterized by greater neurocognitive and functional impairments, or by a distinct trajectory of such deficits. The aim of this study was to compare the neurocognitive and functional course of euthymic BD-P, euthymic BD patients without a history of psychosis (BD-NP), stabilized patients with schizophrenia and healthy subjects, during a five-year follow-up.Methods:Neurocognitive and psychosocial function was examined in 100 euthymic patients with BD (50 BD-P, 50 BD-NP), 50 stabilized patients with schizophrenia (SZ), and 51 healthy controls (HC) at baseline (T1), and after a 5-year follow-up (T2).Results:The course of both neurocognitive performance and functional outcome of patients with SZ and BD (BD-P and BD-NP) is stable. The profile of neurocognitive impairment of patients with SZ or BD (BD-P and BD-NP), is similar, with only quantitative differences circumscribed to certain domains, such as working memory. The subgroup of patients with BD-NP does not show functional deterioration.Conclusions:We have not found evidence of progression in the neurocognitive or psychosocial impairment in any of the three groups of patients, although it cannot be dismissed the possibility of a subset of patients with a progressive course. Other longitudinal studies with larger samples and longer duration are necessary to confirm these findings.

Funder

Instituto de Salud Carlos III, Fondo de Investigación Sanitaria (FIS)

Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)

Madrid Regional Government

JanssenCilag

Lundbeck

Otsuka

Pfizer

Ferrer

Juste

Takeda

AB-Biotics

Allergan

Angelini

AstraZeneca

Bristol-Myers Squibb

Dainippon Sumitomo Pharma

Farmindustria

Forest Research Institute

Gedeon Richter

Glaxo-Smith-Kline

Janssen

Roche

Sanofi-Aventis

Servier

Shire

Sunovion

Brain and Behaviour Foundation

Spanish Ministry of Science and Innovation (CIBERSAM)

Seventh European Framework Programme (ENBREC)

Stanley Medical Research Institute

Publisher

Cambridge University Press (CUP)

Subject

Psychiatry and Mental health

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