Abstract
AbstractSuicidal behavior runs in families and is prevalent in adolescence. Case-control and family-based studies in this age group failed to find a genetic association that survived replications. Gene environment approach gave new hope for possible associations especially with the short allele of the serotonin transporter promoter polymorphism (5-HTTLPR). However, a recent meta-analysis raised doubts about the consistency of these findings. Some new structural and functional imaging data may shade light on the age-related and gender-related development of the brain. This review suggests a new approach to gene by environment and timing interaction to understand the interplay that leads to suicidality in adolescents and young adults.
Publisher
Cambridge University Press (CUP)
Subject
Psychiatry and Mental health
Reference20 articles.
1. Neurobiology of Depression in Children and Adolescents
2. The TDT and other family-based tests for linkage disequilibrium and association;Spielman;Am J Hum Genet,1996
3. Comparison of statistics for candidate-gene association studies using cases and parents;Schaid;Am J Hum Genet,1994
4. Structural Maturation of Neural Pathways in Children and Adolescents: In Vivo Study
5. Statistical properties of the haplotype relative risk
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