Timing is critical: Gene, environment and timing interactions in genetics of suicide in children and adolescents

Author:

Zalsman G.

Abstract

AbstractSuicidal behavior runs in families and is prevalent in adolescence. Case-control and family-based studies in this age group failed to find a genetic association that survived replications. Gene environment approach gave new hope for possible associations especially with the short allele of the serotonin transporter promoter polymorphism (5-HTTLPR). However, a recent meta-analysis raised doubts about the consistency of these findings. Some new structural and functional imaging data may shade light on the age-related and gender-related development of the brain. This review suggests a new approach to gene by environment and timing interaction to understand the interplay that leads to suicidality in adolescents and young adults.

Publisher

Cambridge University Press (CUP)

Subject

Psychiatry and Mental health

Reference20 articles.

1. Neurobiology of Depression in Children and Adolescents

2. The TDT and other family-based tests for linkage disequilibrium and association;Spielman;Am J Hum Genet,1996

3. Comparison of statistics for candidate-gene association studies using cases and parents;Schaid;Am J Hum Genet,1994

4. Structural Maturation of Neural Pathways in Children and Adolescents: In Vivo Study

5. Statistical properties of the haplotype relative risk

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3