Exploration of synthetic multifunctional amides as new therapeutic agents for Alzheimer's disease through enzyme inhibition, chemoinformatic properties, molecular docking and dynamic simulation insights

Author:

Hassan Mubashir,Abbasi Muhammad Athar,Aziz-ur-Rehman ,Siddiqui Sabahat Zahra,Hussain Ghulam,Shah Syed Adnan Ali,Shahid Muhammad,Seo Sung-Yum

Funder

National Research Foundation of Korea

NRF

Ministry of Education

Publisher

Elsevier BV

Subject

Applied Mathematics,General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Modelling and Simulation,General Medicine,Statistics and Probability

Reference86 articles.

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2. Synthesis of brominated 2-phenitidine derivatives as valuable inhibitors of cholinesterases for the treatment of Alzheimer's disease;Abbasi;Iran J. Pharm. Res.,2014

3. Synthetic N-(alkyl/aralkyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-methylbenzenesulfonamides as acetyl cholinesterase inhibitors;Abbasi;Novel Approaches Drug Des. Dev.,2017

4. Molecular dynamics studies of AChBP with nicotine and carbamylcholine: the role of water in the binding pocket;Amiri;Protein Eng. Des. Selection,2007

5. Synthesis, structural analysis, and screening of some novel 5-substituted aryl/aralkyl-1,3,4-oxadiazole-2-yl 4-(morpholine-4-ylsulfonyl)benzyl sulfides as potential antibacterial agents;Aziz-ur-Rehman;Phosphorus Sulfur Silicon Relat. Elem.,2015

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