Low-dose microcystin-LR antagonizes aflatoxin B1 induced hepatocarcinogenesis through decreasing cytochrome P450 1A2 expression and aflatoxin B1-DNA adduct generation

Author:

Wang Lingqiao,He Lixiong,Zeng Hui,Fu Wenjuan,Wang Jia,Tan Yao,Zheng Chuanfen,Qiu Zhiqun,Luo Jiaohua,Lv Chen,Huang Yujing,Shu Weiqun

Funder

National Natural Science Foundation of China

Natural Science Foundation of Chongqing

Publisher

Elsevier BV

Subject

General Medicine,General Chemistry,Environmental Chemistry,Environmental Engineering,Pollution,Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference36 articles.

1. Cytochrome P450 isoforms are differently up-regulated in aflatoxin B(1)-exposed human lymphocytes and monocytes;Bahari;Immunopharmacol. Immunotoxicol.,2014

2. Aflatoxin B1-induced DNA damage and its repair;Bedard;Canc. Lett.,2006

3. Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells;Chen;Toxicol. Lett.,2018

4. Changing rates for liver and lung cancers in Qidong, China;Chen;Chem. Res. Toxicol.,2014

5. The role of GSH in microcystin-induced apoptosis in rat liver: involvement of oxidative stress and NF-kappaB;Chen;Environ. Toxicol.,2016

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