Synthesis of novel 21-trifluoropregnane steroids: Inhibitors of 17α-hydroxylase/17,20-lyase (17α-lyase)-Reference-Cited by-同舟云学术

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Synthesis of novel 21-trifluoropregnane steroids: Inhibitors of 17α-hydroxylase/17,20-lyase (17α-lyase)

Published:1997-06 Issue:6 Volume:62 Page:468-473
ISSN:0039-128X
Container-title:Steroids
language:en
Short-container-title:Steroids

Author:

Njar Vincent C.O.,Klus Gregory T.,Johnson Hausa H.,Brodie Angela M.H.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Pharmacology,Endocrinology,Molecular Biology,Biochemistry

Reference33 articles.

1. Microsomal cytochrome P-450 from neonatal pig testis: Two enzymatic activities (17-hydroxlase and C17,20-lyase) associated with one protein;Nakajin;Biochemistry,1981

2. Testicular microsomal cytochrome P-450 for C21 steroid side-chain cleavage: Spectral and binding studies;Nakajin;J Biol Chem,1981

3. 17α-Hydroxylase/17-20-lyase;Bossche,1994

4. P450-dependent enzymes as targets for prostate cancer therapy;De Coster;J Steroid Biochem Molec Biol,1996

5. 4-Pregnene-3-20β-carboxaldehyde: A potent inhibitor of 17α-hydroxylase/C17,20-lyase and 5α-reductase;Li;J Steroid Biochem Molec Biol,1992

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4. A facile access to novel steroidal 17-2′-(1′,3′,4′)-oxadiazoles, and an evaluation of their cytotoxic activities in vitro;Bioorganic & Medicinal Chemistry Letters;2014-03

5. Synthesis of halogenated pregnanes, mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2;The Journal of Steroid Biochemistry and Molecular Biology;2012-01

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