A straightforward chemical synthesis of 17-ketosteroids by cleavage of the C-17-dihydroxy acetone side chain in corticosteroids

Author:

Le Pera Adolfo,Leggio Antonella,Siciliano Carlo,Di Gioia Maria L,Napoli Anna,Sindona Giovanni,Liguori Angelo

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Pharmacology,Endocrinology,Molecular Biology,Biochemistry

Reference14 articles.

1. Oliveto EP. Synthesis and degradation of the pregnane side-chain. In: Fried J, Edwards JA, editors. Organic reactions in steroid chemistry, vol. 2. New York: Van Nostrand Reinhold Co.; 1972. p. 127–236.

2. A facile approach to steroidal 20-hydroxy-17(20)-en-21-aldehydes: important intermediates in the biological 17-dehydroxylation of C-17 dihydroxyacetone steroids;Di Gioia;Tetrahedron Lett.,2001

3. 11β,20-dihydroxy-3-oxopregna-4,17(20)-dien-21-al: an intermediate in the biological 17-dehydroxylation of cortisol;Singer;Endocrinology,1986

4. A simple two-step method for the conversion of [3H]cortisol to [3H]-11-ketotestosterone;Lockman;Steroids,1997

5. The first chemical synthesis of wortmannin by starting from hydrocortisone;Sato;Tetrahedron Lett.,1996

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