A computational pipeline for identifying gene targets and signalling pathways in cancer cells to improve lymphocyte infiltration and immune checkpoint therapy efficacy

Author:

Nasr Sahar,Li Lin,Asad MohammadORCID,Moridi Mahroo,Wang Megan,Zemp Franz J.,Mahoney Douglas J.,Wang Edwin

Funder

Alberta Innovates

Alberta Innovates Health Solutions

Canadian Institutes of Health Research

Publisher

Elsevier BV

Reference67 articles.

1. The blockade of immune checkpoints in cancer immunotherapy;Pardoll;Nat Rev Cancer,2012

2. Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies;Wang;J Hematol Oncol,2019

3. Immune checkpoint inhibitor (ICI) combination therapy compared to monotherapy in advanced solid cancer: a systematic review;Ma;J Cancer,2021

4. Hallmarks of resistance to immune-checkpoint inhibitors;Karasarides;Cancer Immunol Res,2022

5. Association of germline variants in natural killer cells with tumor immune microenvironment subtypes, tumor-infiltrating lymphocytes, immunotherapy response, clinical outcomes, and cancer risk;Xu;JAMA Netw Open,2019

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