Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1-Reference-Cited by-同舟云学术

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1

Published:2017-10 Issue: Volume:24 Page:93-101
ISSN:2352-3964
Container-title:EBioMedicine
language:en
Short-container-title:EBioMedicine

Author:

Raven Frank,Ward Joseph F.,Zoltowska Katarzyna M.,Wan Yu,Bylykbashi Enjana,Miller Sean J.,Shen Xunuo,Choi Se Hoon,Rynearson Kevin D.,Berezovska Oksana,Wagner Steven L.,Tanzi Rudolph E.,Zhang Can

Funder

National Institute of Health

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference54 articles.

1. Evidence of a novel mechanism for partial gamma-secretase inhibition induced paradoxical increase in secreted amyloid beta protein;Barnwell;PLoS One,2014

2. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons;Berezovska;Brain Res. Mol. Brain Res.,1999

3. Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses;Bertram;Nat. Rev.,2008

4. Amyloid-PET predicts inhibition of de novo plaque formation upon chronic gamma-secretase modulator treatment;Brendel;Mol. Psychiatry,2015

5. The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression;Burton;J. Biol. Chem.,2008

Cited by 25 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS);The Lancet Neurology;2024-09

2. Targeting myeloperoxidase to reduce neuroinflammation in X-linked dystonia parkinsonism;2024-06-25

3. How Modulator Binding at the Amyloidβ-γ-Secretase Interface Enhances Substrate Binding and Attenuates Membrane Distortion;Journal of Medicinal Chemistry;2023-12-07

4. PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer’s disease;2023-11-07

5. Functional variations in gamma-secretase activity are critical determinants of the clinical, biomarker, and cognitive progression of autosomal dominant Alzheimer’s disease;2023-07-05