The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients

Author:

Alexander James L.ORCID,Mullish Benjamin H.ORCID,Danckert Nathan P.ORCID,Liu ZhigangORCID,Olbei Marton L.,Saifuddin AamirORCID,Torkizadeh Melissa,Ibraheim Hajir,Blanco Jesús Miguéns,Roberts Lauren A.ORCID,Bewshea Claire M.,Nice Rachel,Lin SimengORCID,Prabhudev Hemanth,Sands Caroline,Horneffer-van der Sluis Verena,Lewis Matthew,Sebastian Shaji,Lees Charlie W.,Teare Julian P.,Hart Ailsa,Goodhand James R.,Kennedy Nicholas A.,Korcsmaros Tamas,Marchesi Julian R.,Ahmad Tariq,Powell NickORCID

Funder

NIHR Imperial Biomedical Research Centre

National Institute for Health and Care Research

NIHR Exeter Clinical Research Facility

Imperial College London

Medical Research Council

Imperial College Healthcare NHS Trust

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference56 articles.

1. Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study;Lopez Bernal;BMJ (Clinical research ed),2021

2. Duration of protection against mild and severe disease by covid-19 vaccines;Andrews;N Engl J Med,2022

3. Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD;Kennedy;Gut,2021

4. COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case-control study;Alexander;Lancet Gastroenterol Hepatol,2022

5. Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab;Lin;Nat Commun,2022

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