Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport-Reference-Cited by-同舟云学术

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport

Published:2017-10 Issue: Volume:24 Page:76-92
ISSN:2352-3964
Container-title:EBioMedicine
language:en
Short-container-title:EBioMedicine

Author:

Ruderisch Nadine,Schlatter Daniel,Kuglstatter Andreas,Guba Wolfgang,Huber Sylwia,Cusulin Carlo,Benz Jörg,Rufer Arne Christian,Hoernschemeyer Joerg,Schweitzer Christophe,Bülau Tina,Gärtner Achim,Hoffmann Eike,Niewoehner Jens,Patsch Christoph,Baumann Karlheinz,Loetscher Hansruedi,Kitas Eric,Freskgård Per-Ola

Funder

Innovative Medicines Initiative Joint Undertaking

European Union's Seventh Framework Programme

F. Hoffmann-La Roche

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference41 articles.

1. A therapeutic antibody targeting BACE1 inhibits amyloid-beta production in vivo;Atwal;Sci. Transl. Med.,2011

2. Specific inhibition of beta-secretase processing of the Alzheimer disease amyloid precursor protein;Ben Halima;Cell Rep.,2016

3. Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening;Boissart;Transl. Psychiatry,2013