The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

Author:

Lill Christina M.12,Rengmark Aina3,Pihlstrøm Lasse3,Fogh Isabella4,Shatunov Aleksey4,Sleiman Patrick M.567,Wang Li‐San8,Liu Tian9,Lassen Christina F.10,Meissner Esther2,Alexopoulos Panos11,Calvo Andrea12,Chio Adriano1213,Dizdar Nil14,Faltraco Frank15,Forsgren Lars16,Kirchheiner Julia17,Kurz Alexander11,Larsen Jan P.18,Liebsch Maria2,Linder Jan16,Morrison Karen E.1920,Nissbrandt Hans21,Otto Markus17,Pahnke Jens2223,Partch Amanda8,Restagno Gabriella24,Rujescu Dan25,Schnack Cathrin17,Shaw Christopher E.4,Shaw Pamela J.26,Tumani Hayrettin17,Tysnes Ole‐Bjørn2728,Valladares Otto8,Silani Vincenzo2930,Berg Leonard H.31,Rheenen Wouter31,Veldink Jan H.31,Lindenberger Ulman9,Steinhagen‐Thiessen Elisabeth32,Teipel Stefan3334,Perneczky Robert113536,Hakonarson Hakon567,Hampel Harald3738,Arnim Christine A.F.17,Olsen Jørgen H.10,Van Deerlin Vivianna M.8,Al‐Chalabi Ammar4,Toft Mathias3,Ritz Beate39,Bertram Lars1235,

Affiliation:

1. Platform for Genome Analytics Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck Lübeck Germany

2. Department of Vertebrate Genomics Max Planck Institute for Molecular Genetics Berlin Germany

3. Department of Neurology Oslo University Hospital Oslo Norway

4. Department of Clinical Neuroscience Institute of Psychiatry, King's College London London UK

5. Center for Applied Genomics Abramson Research Center, The Children's Hospital of Philadelphia Philadelphia PA USA

6. Division of Human Genetics Abramson Research Center, The Children's Hospital of Philadelphia Philadelphia PA USA

7. Department of Pediatrics Perelman School of Medicine, University of Pennsylvania Philadelphia PA USA

8. Department of Pathology and Laboratory Medicine Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA

9. Max Planck Institute for Human Development Berlin Germany

10. Institute of Cancer Epidemiology Danish Cancer Society Copenhagen Denmark

11. Department of Psychiatry and Psychotherapy Technische Universität München Munich Germany

12. Rita Levi Montalcini Department of Neuroscience, ALS Center University of Torino Torino Italy

13. Neuroscience Institute of Turin Turin Italy

14. Department of Neurology Linköping University Linköping Sweden

15. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy Goethe University of Frankfurt Frankfurt Germany

16. Department of Pharmacology and Clinical Neuroscience Umeå University Umeå Sweden

17. Department of Neurology University of Ulm Ulm Germany

18. The Norwegian Centre for Movement Disorders Stavanger University Hospital Stavanger Norway

19. School of Clinical and Experimental Medicine, College of Medical and Dental Sciences University of Birmingham Birmingham UK

20. Neurosciences Division University Hospitals Birmingham NHS Foundation Trust Birmingham UK

21. Department of Pharmacology The Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden

22. Department of Neuro‐/Pathology University of Oslo and Oslo University Hospital Oslo Norway

23. Lübeck Institute of Experimental Dermatology University of Lübeck Lübeck Germany

24. Department of Clinical Pathology Molecular Genetics Unit, Azienda Ospedaliera Città della Salute e della Scienza Torino Italy

25. Department of Psychiatry University of Halle‐Wittenberg Halle Germany

26. Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), Faculty of Medicine, Dentistry and Health University of Sheffield Sheffield UK

27. Department of Neurology Haukeland University Hospital Bergen Norway

28. Department of Clinical Medicine University of Bergen Bergen Norway

29. Department of Neurology and Laboratory of Neuroscience IRCCS Istituto Auxologico Italiano Milano Italy

30. Department of Pathophysiology and Tranplantation, “Dino Ferrari” Center Università degli Studi di Milano Milano Italy

31. Department of Neurology, Neuromuscular Diseases Brain Center Rudolf Magnus, Netherlands ALS Center University Medical Center Utrecht Utrecht The Netherlands

32. Interdisciplinary Metabolic Center, Lipids Clinic Charité University Medicine Berlin Germany

33. German Center for Neurodegenerative Diseases (DZNE) Rostock Germany

34. Department of Psychosomatic Medicine University of Rostock Rostock Germany

35. Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine The Imperial College of Science, Technology, and Medicine London UK

36. West London Cognitive Disorders Treatment and Research Unit, West London Mental Health Trust London UK

37. AXA Research Fund & UPMC Chair Paris France

38. Département de Neurologie Sorbonne Universités, Université Pierre et Marie Curie, Institut de la Mémoire et de la Maladie d'Alzheimer & Institut du Cerveau et de la Moelle épinière (ICM), Hôpital de la Pitié‐Salpétrière Paris France

39. Department of Epidemiology and Environmental Sciences, School of Public Health University of California Los Angeles CA USA

Funder

Cure Alzheimer's Fund

Michael J. Fox Foundation for Parkinson's Research

German Ministry for Education and Research

BMBF

Michael J. Fox Foundation

Max Planck Society

Katharina-Hardt-Stiftung

AXA Research Fund

Fondation Université Pierre et Marie Curie

Fondation pour la Recherche sur Alzheimer

MND Association

Research Council of Norway and the South-Eastern Norway Regional Health Authority

NIEHS of the National Institutes of Health

European Union

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Clinical Neurology,Developmental Neuroscience,Health Policy,Epidemiology

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