Amyloid β synaptotoxicity is Wnt‐PCP dependent and blocked by fasudil-Reference-Cited by-同舟云学术

Amyloid β synaptotoxicity is Wnt‐PCP dependent and blocked by fasudil

Published:2017-10-19 Issue:3 Volume:14 Page:306-317
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Sellers Katherine J.¹,Elliott Christina¹,Jackson Joshua²,Ghosh Anshua¹,Ribe Elena³,Rojo Ana I.⁴,Jarosz‐Griffiths Heledd H.⁵,Watson Iain A.¹,Xia Weiming⁶,Semenov Mikhail⁶,Morin Peter⁶,Hooper Nigel M.⁵,Porter Rod⁷,Preston Jane⁸,Al‐Shawi Raya⁹,Baillie George¹⁰,Lovestone Simon³,Cuadrado Antonio⁴,Harte Michael²,Simons Paul⁹,Srivastava Deepak P.¹,Killick Richard¹

Affiliation:

1. King's College London Maurice Wohl Clinical Neuroscience Institute London UK

2. The University of Manchester Faculty of Biology, Medicine and Health, Division of Pharmacy and Optometry Manchester UK

3. University of Oxford Department of Psychiatry, Warneford Hospital Oxford UK

4. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED). Instituto de Investigación Sanitaria La Paz (IdiPaz) Autonomous University of Madrid Madrid Spain

5. The University of Manchester Faculty of Biology, Medicine and Health, Division of Neuroscience and Experimental Psychology Manchester UK

6. Boston University School of Medicine New England Geriatric Research Education and Clinical Center Boston USA

7. Rod Porter Rod Porter Consultancy Baldock England UK

8. King's College London Institute of Pharmaceutical Science Franklin‐Wilkins Building London UK

9. University College London Centre for Amyloidosis and Acute Phase Proteins Royal Free Campus London UK

10. University of Glasgow, Institute of Cardiovascular and Medical Science Glasgow Scotland

Funder

Medical Research Council

Alzheimer's Research Trust

MRC

ARUK

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Clinical Neurology,Developmental Neuroscience,Health Policy,Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1016/j.jalz.2017.09.008

Reference50 articles.

1. EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-β Oligomers

2. Synaptic changes in Alzheimer’s disease and its models

3. Diffusible, nonfibrillar ligands derived from A 1-42 are potent central nervous system neurotoxins

4. Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

5. Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

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