Association of branched‐chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

Author:

Tynkkynen Juho1,Chouraki Vincent234,Lee Sven J.5,Hernesniemi Jussi1,Yang Qiong36,Li Shuo36,Beiser Alexa236,Larson Martin G.36,Sääksjärvi Katri7,Shipley Martin J.8,Singh‐Manoux Archana89,Gerszten Robert E.101112,Wang Thomas J.13,Havulinna Aki S.7,Würtz Peter1415,Fischer Krista16,Demirkan Ayse5,Ikram M. Arfan51718,Amin Najaf5,Lehtimäki Terho1920,Kähönen Mika2122,Perola Markus71516,Metspalu Andres16,Kangas Antti J.14,Soininen Pasi142324,Ala‐Korpela Mika2324252627,Vasan Ramachandran S.328,Kivimäki Mika829,Duijn Cornelia M.530,Seshadri Sudha2331,Salomaa Veikko7

Affiliation:

1. Department of CardiologyTays Heart HospitalTampere University Hospital and Faculty of Medicine and Life SciencesUniversity of TampereTampereFinland

2. Department of NeurologyBoston University School of MedicineBostonMAUSA

3. The Framingham Heart StudyFraminghamMAUSA

4. Lille UniversityInsermLille University HospitalInstitut Pasteur de LilleU1167 ‐ RID‐AGE ‐ Risk Factors and Molecular Determinants of Aging‐Related DiseasesLabex DistalzLilleFrance

5. Department of EpidemiologyErasmusMCRotterdamThe Netherlands

6. Department of BiostatisticsBoston University School of Public HealthBostonMAUSA

7. Department of HealthNational Institute for Health and WelfareHelsinkiFinland

8. Department of Epidemiology and Public HealthUniversity College LondonLondonUK

9. INSERM, U1018Centre for Research in Epidemiology and Population HealthFrance

10. Cardiology Division, Department of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

11. Broad Institute of MIT and HarvardCambridgeMAUSA

12. Cardiovascular Research CenterMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

13. Vanderbilt Heart and Vascular InstituteVanderbilt University School of MedicineNashvilleTNUSA

14. Nightingale Health LtdHelsinkiFinland

15. Research Programs UnitDiabetes and ObesityUniversity of HelsinkiHelsinkiFinland

16. Estonian Genome CenterUniversity of TartuTartuEstonia

17. Department of Radiology and Nuclear MedicineErasmus MCRotterdamThe Netherlands

18. Department of NeurologyErasmus MCRotterdamThe Netherlands

19. Department of Clinical ChemistryFimlab LaboratoriesTampereFinland

20. Department of Clinical ChemistryFinnish Cardiovascular Research Center ‐ TampereFaculty of Medicine and Life SciencesUniversity of TampereTampereFinland

21. Department of Clinical PhysiologyTampere University HospitalTampereFinland

22. Department of Clinical PhysiologyFinnish Cardiovascular Research Center ‐ TampereFaculty of Medicine and Life SciencesUniversity of TampereTampereFinland

23. Computational MedicineFaculty of MedicineUniversity of Oulu and Biocenter OuluOuluFinland

24. NMR Metabolomics LaboratorySchool of PharmacyUniversity of Eastern FinlandKuopioFinland

25. Population Health ScienceBristol Medical SchoolUniversity of BristolBristolUK

26. Medical Research Council Integrative Epidemiology Unit at the University of BristolBristolUK

27. Systems EpidemiologyBaker Heart and Diabetes InstituteMelbourneVictoriaAustralia

28. Department of Medicine, Sections of Preventive Medicine and CardiologyBoston University School of MedicineBostonMAUSA

29. ClinicumFaculty of MedicineUniversity of HelsinkiHelsinkiFinland

30. Leiden Academic Center for Drug Reseach (LACDR)Leiden UniversityLeidenThe Netherlands

31. Glenn Biggs Institute for Alzheimer's and Neurodegenerative DiseasesUniversity of Texas Health Sciences CenterSan AntonioTXUSA

Funder

Sydäntutkimussäätiö

Academy of Finland

Internationale Stichting Alzheimer Onderzoek

Hersenstichting

Oracle

Ministerie van Onderwijs, Cultuur en Wetenschap

Directorate-General XII, Science, Research, and Development

Erasmus Medisch Centrum

British Heart Foundation

National Institutes of Health

National Institute on Aging

National Institute of Neurological Disorders and Stroke

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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