Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Author:

Shi Liu1,Westwood Sarah1,Baird Alison L.1,Winchester Laura1,Dobricic Valerija2,Kilpert Fabian2,Hong Shengjun2,Franke Andre3,Hye Abdul4,Ashton Nicholas J.4567,Morgan Angharad R.8,Bos Isabelle9,Vos Stephanie J.B.10,Buckley Noel J.1,Kate Mara ten10,Scheltens Philip10,Vandenberghe Rik11,Gabel Silvy1112,Meersmans Karen1112,Engelborghs Sebastiaan13141516,De Roeck Ellen E.131415,Sleegers Kristel1517,Frisoni Giovanni B.1819,Blin Olivier20,Richardson Jill C.21,Bordet Régis22,Molinuevo José L.2324,Rami Lorena24,Wallin Anders25,Kettunen Petronella2526,Tsolaki Magda27,Verhey Frans9,Lleó Alberto28,Alcolea Daniel29,Popp Julius3031,Peyratout Gwendoline30,Martinez-Lage Pablo32,Tainta Mikel32,Johannsen Peter33,Teunissen Charlotte E.34,Freund-Levi Yvonne353637,Frölich Lutz38,Legido-Quigley Cristina3940,Barkhof Frederik4142,Blennow Kaj543,Zetterberg Henrik5434445,Baker Susan46,Morgan B. Paul8,Streffer Johannes1447,Visser Pieter Jelle91048,Bertram Lars249,Lovestone Simon150,Nevado-Holgado Alejo J.1

Affiliation:

1. Department of Psychiatry; University of Oxford; Oxford UK

2. Lübeck Interdisciplinary Platform for Genome Analytics; Institutes of Neurogenetics and Cardiogenetics, University of Lübeck; Lübeck Germany

3. Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel; Kiel Germany

4. Maurice Wohl Clinical Neuroscience; Institute of Psychiatry, Psychology and Neuroscience, Kings College London; London UK

5. Department of Psychiatry and Neurochemistry; University of Gothenburg; Mölndal Sweden

6. Wallenberg Centre for Molecular & Translational Medicine; University of Gothenburg; Gothenburg Sweden

7. NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation; London UK

8. Dementia Research Institute Cardiff; Cardiff University; Cardiff UK

9. Department of Psychiatry and Neuropsychology; School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University; Maastricht the Netherlands

10. Alzheimer Center, VU University Medical Center; Amsterdam the Netherlands

11. University Hospital Leuven; Leuven Belgium

12. Laboratory for Cognitive Neurology, Department of Neurosciences; KU Leuven; Belgium

13. Center for Neurosciences, Vrije Universiteit Brussel (VUB); Brussels Belgium

14. Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp; Antwerp Belgium

15. Institute Born-Bunge, University of Antwerp; Antwerp Belgium

16. Department of Neurology; VUB University Hospital Brussels (UZ Brussel); Brussels Belgium

17. Neurodegenerative Brain Diseases Group; Center for Molecular Neurology, VIB; Edegem Belgium

18. University of Geneva; Geneva Switzerland

19. IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli; Brescia Italy

20. AIX Marseille University, INS, Ap-hm; Marseille France

21. Neurosciences Therapeutic Area; GlaxoSmithKline R&D; Stevenage UK

22. University of Lille, Inserm, CHU Lille; Lille France

23. Alzheimer's disease & other cognitive disorders unit; Hopsital Clínic-IDIBAPS; Barcelona Spain

24. Barcelona Beta Brain Research Center, Universitat Pompeu Fabra; Barcelona Spain

25. Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Gothenburg Sweden

26. Nuffield Department of Clinical Neurosciences; University of Oxford; Oxford UK

27. 1st Department of Neurology; AHEPA University Hospital; Makedonia Thessaloniki Greece

28. Hospital de la Santa Creu i Sant Pau; Barcelona Spain

29. Department of Neurology; Hospital de la Santa Creu i Sant Pau; Barcelona Spain

30. University Hospital of Lausanne; Lausanne Switzerland

31. Geriatric Psychiatry, Department of Mental Health and Psychiatry; Geneva University Hospitals; Geneva Switzerland

32. CITA-Alzheimer Foundation; San Sebastian Spain

33. Danish Dementia Research Centre; Rigshospitalet, Copenhagen University Hospital; Copenhagen Denmark

34. Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience; Amsterdam University Medical Centers, Vrije Universiteit; Amsterdam The Netherlands

35. Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics; Karolinska Institutet; Department of Geriatric Medicine; Karolinska University Hospital Huddinge; Stockholm Sweden

36. Department of Psychiatry in Region Örebro County and School of Medical Sciences, Faculty of Medicine and Health; Örebro University; Örebro Sweden

37. Department of Old Age Psychiatry, Psychology and Neuroscience; Kings College London; London UK

38. Department of Geriatric Psychiatry; Zentralinstitut für Seelische Gesundheit, University of Heidelberg; Mannheim Germany

39. Kings College London; London UK

40. The Systems Medicine Group, Steno Diabetes Center; Gentofte Denmark

41. Department of Radiology and Nuclear Medicine; VU University Medical Center; Amsterdam The Netherland

42. UCL Institutes of Neurology and Healthcare Engineering; London UK

43. Clinical Neurochemistry Laboratory; Sahlgrenska University Hospital; Mölndal Sweden

44. UK Dementia Research Institute at UCL; London UK

45. Department of Neurodegenerative Disease; UCL Institute of Neurology; London UK

46. Janssen R&D; Titusville NJ USA

47. Janssen R&D, LLC; Beerse Belgium

48. Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics; Karolinska Institutet; Stockholm Sweden

49. Department of Psychology; University of Oslo; Oslo Norway

50. Janssen-Cilag UK, formerly Department of Psychiatry; University of Oxford; Oxford UK

Funder

Innovative Medicines Initiative

Seventh Framework Programme

European Federation of Pharmaceutical Industries and Associations

European Commission

Stichting voor Alzheimer Onderzoek

Department of Health, Australian Government

Department of Health of the Basque Government

Universiteit Antwerpen

NIHR

DPUK

UK Medical Research Council

Seventh Framework Program

EFPIA

Department of Health

Basque Government

University of Antwerp

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Clinical Neurology,Developmental Neuroscience,Health Policy,Epidemiology

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