Carriers of a common variant in the dopamine transporter gene have greater dementia risk, cognitive decline, and faster ventricular expansion

Author:

Roussotte Florence F.12,Gutman Boris A.2,Hibar Derrek P.2,Madsen Sarah K.2,Narr Katherine L.13,Thompson Paul M.1234,

Affiliation:

1. Department of Neurology David Geffen School of Medicine at UCLA Los Angeles CA USA

2. Imaging Genetics Center, Institute for Neuroimaging and Informatics Department of Neurology, Keck/USC School of Medicine University of Southern California Los Angeles CA USA

3. Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine at UCLA Los Angeles CA USA

4. Departments of Psychiatry, Engineering, Radiology, & Ophthalmology, Keck/USC School of Medicine University of Southern California Los Angeles CA USA

Funder

A.P. Giannini Foundation

National Institutes of Health

Alzheimer's Disease Neuroimaging Initiative

National Institute on Aging

National Institute of Biomedical Imaging and Bioengineering

National Institutes of Health Grant

the National Institute of Biomedical Imaging and Bioengineering

Alzheimer's Association

Alzheimer's Drug Discovery Foundation

BioClinica, Inc.

Biogen Idec Inc.

Bristol-Myers Squibb Company

Eisai Inc.

Elan Pharmaceuticals, Inc.

Eli Lilly and Company

F. Hoffmann-La Roche Ltd

Genentech, Inc.

GE Healthcare

Innogenetics, N.V.

IXICO Ltd.

Janssen Alzheimer Immunotherapy Research & Development, LLC.

Johnson & Johnson Pharmaceutical Research & Development LLC.

Medpace, Inc.

Merck & Co., Inc.

Meso Scale Diagnostics, LLC.

NeuroRx Research

Novartis Pharmaceuticals Corporation

Pfizer Inc.

Piramal Imaging; Servier

Synarc Inc.

Takeda Pharmaceutical Company

Canadian Institutes of Health Research

Northern California Institute for Research and Education

NIH

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Reference69 articles.

1. Dopamine and the regulation of cognition and attention

2. SchuckNW FrenschPA SchjeideBM SchroderJ BertramL et al.Effects of aging and dopamine genotypes on the emergence of explicit memory during sequence learning.Neuropsychologia2013

3. Association analysis of dopaminergic gene variants (Comt, Drd4 And Dat1) with Alzheimer s disease;Lin WY;J Biol Regul Homeost Agents,2012

4. Genomic Features of the Human Dopamine Transporter Gene and Its Potential Epigenetic States: Implications for Phenotypic Diversity

5. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

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