Changes in phosphoinositide signalling activity and levels of the alpha subunit of Gq/11 protein in rat brain induced by E-5842, a sigma1 receptor ligand and potential atypical antipsychotic

Author:

Romero Gonzalo,Pérez M.Pilar,Carceller Alicia,Monroy Xavier,Farré Antoni J,Guitart Xavier

Publisher

Elsevier BV

Subject

General Neuroscience

Reference20 articles.

1. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary gland;Berridge;Biochem. J.,1982

2. Investigation of the mechanism by which sigma ligands inhibit stimulation of phosphoinositide metabolism by muscarinic cholinergic agonists;Bowen;Prog. Clin. Biol. Res.,1990

3. Carbachol in the presence of guanosine 5′-O-(3-thiotriphosphate) stimulates the breakdown of phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol by rat brain membranes;Claro;J. Biol. Chem.,1989

4. Effects of treatment with haloperidol, chlorpromazine, and clozapine on protein kinase C (PKC) and phosphoinositide-specific phopsholipase C (PI-PLC) activity and on mRNA and protein expression of PKC and PLC isozymes in rat brain;Dwivedi;J. Pharmacol. Exp. Ther.,1999

5. BMY 14,802, a sigma receptor ligand for the treatment of schizophrenia;Gewirtz;Neuropsychopharmacology,1994

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