Increased phosphorylation of HexM improves lysosomal uptake and potential for managing GM2 gangliosidoses

Author:

Benzie Graeme,Bouma Kristen,Battellino Taylor,Cooper Steven,Hemming Rick,Kammouni Wafa,Liu Lin,Do Cuong,Khajehpour Mazdak,Perreault Helene,Kornfeld Stuart,Triggs-Raine Barbara,Mark Brian L.

Funder

Canadian Glycomics Network

Canadian Institutes of Health Research

Publisher

Elsevier BV

Reference39 articles.

1. The GM2 gangliosidoses;Gravel,2001

2. Purification and characterization of an activator protein for the degradation of glycolipids GM2 and GA2 by hexosaminidase A, Hoppe-Seylers Zeitschrift Für Physiol;Conzelmann;Chemie,1979

3. Neurite atrophy and apoptosis mediated by PERK signaling after accumulation of GM2-ganglioside;Virgolini;Biochim. Biophys. Acta - Mol. Cell Res.,2019

4. Gangliosides and gangliosidoses: Principles of molecular and metabolic pathogenesis;Sandhoff;J. Neurosci.,2013

5. Partial enzyme deficiencies: residual activities and the development of neurological disorders;Conzelmann;Dev. Neurosci.,1983

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