Effective lowly cytotoxic analogs of an HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II)

Author:

Tamamura Hirokazu,Arakaki Rieko,Funakoshi Hanae,Imai Makoto,Otaka Akira,Ibuka Toshiro,Nakashima Hideki,Murakami Tsutomu,Waki Michinori,Matsumoto Akiyoshi,Yamamoto Naoki,Fujii Nobutaka

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Abbreviations used: T22, [Tyr5,12 Lys7]-polyphemusin II; TW70, des-[Cys8,13, Tyr9,12]-[d-Lys10, Pro11]-T22); HIV, human immunodeficiency virus; AZT, 3′-azido-2′, 3′-dideoxythymidine; AIDS, acquired immunodeficiency syndrome; EC50, 50% effective concentration; CC50, 50% cytotoxic concentration; Fmoc, 9-fluorenylmethyloxycarbonyl; DIPCDI, 1,3-diisopropylcarbodiimide; HOBt, N-hydroxybenzotriazole; Alko, p-benzyloxybenzyl alcohol; But, tert-butyl; Mtr, 4-methoxy-2,3,6-trimethylphenylsulfonyl; MBzl, 4-methoxybenzyl; TMSBr, trimethylsilyl bromide; SI, selectivity index; IC50, 50% inhibitory concentration; IF, immunofluorescence; TFA, trifluoroacetic acid; DMF, N,N-dimethylformamide; ddC, 2′,3′-dideoxycytidine.

2. Mitsuya H. J Clin Exp Med (Tokyo) 1996;176:108.

3. (a) Nakamura T, Furunaka H, Miyata T, Tokunaga F, Muta T, Iwanaga S, Niwa M, Takao T, Shimonishi Y. J Biol Chem 1988;263:16709 (b) Miyata T, Tokunaga F, Yoneya T, Yoshikawa K, Iwanaga S, Niwa M, Takao T, Shimonishi Y. J Biochem 1989;106:663 (c) Muta T, Fujimoto T, Nakajima H, Iwanaga S. ibid 1990;108:261.

4. (a) Morimoto M, Mori H, Otake T, Ueba N, Kunita N, Niwa M, Murakami T, Iwanaga S. Chemotherapy 1991;37:206 (b) Murakami T, Niwa M, Tokunaga F, Miyata T, Iwanaga S. ibid 1991;37:327.

5. (a) Masuda M, Nakashima H, Ueda T, Naba H, Ikoma R, Otaka A, Terakawa Y, Tamamura H, Ibuka T, Murakami T, Koyanagi Y, Waki M, Matsumoto A, Yamamoto N, Funakoshi S, Fujii N. Biochem Biophys Res Commun 1992;189:845 (b) Tamamura H, Otaka A, Takada W, Terakawa Y, Yoshizawa H, Masuda M, Ibuka T, Murakami T, Nakashima H, Waki M, Matsumoto A, Yamamoto N, Fujii N. Chem Pharm Bull 1995;43:12 (c) Tamamura H, Otaka A, Murakami T, Ibuka T, Sakano K, Waki M, Matsumoto A, Yamamoto N, Fujii N. Biochem Biophys Res Commun 1996;229:648.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3