High affinity central benzodiazepine receptor ligands. Part 2: quantitative structure–activity relationships and comparative molecular field analysis of pyrazolo[4,3- c ]quinolin-3-ones-Reference-Cited by-同舟云学术

High affinity central benzodiazepine receptor ligands. Part 2: quantitative structure–activity relationships and comparative molecular field analysis of pyrazolo[4,3- c ]quinolin-3-ones

Published:2001-02 Issue:2 Volume:9 Page:431-444
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Savini L.,Chiasserini L.,Pellerano C.,Biggio G.,Maciocco E.,Serra M.,Cinone N.,Carrieri A.,Altomare C.,Carotti A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference71 articles.

1. GABA agonists and antagonists

2. GABA and Benzodiazepine Receptors; Squires, R., Ed.; CRC: Boca Raton, 1988; Vols. 1 and 2.

3. Bernard, E. A. In GABAA Receptor and Anxiety. From Neurobiology to Treatment; Biggio, G., Sanna, E., Costa, E., Eds.; Raven: New York, 1995; pp 1–16.

4. An update on GABAA receptors

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