Bromal-derived tetrahydro-β-carbolines as neurotoxic agents: chemistry, impairment of the dopamine metabolism, and inhibitory effects on mitochondrial respiration

Author:

Bringmann Gerhard,Feineis Doris,Brückner Ralph,Blank Michael,Peters Karl,Peters Eva-Maria,Reichmann Heinz,Janetzky Bernd,Grote Christoph,Clement Hans-Willi,Wesemann Wolfgang

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference55 articles.

1. Neurobiology of tetrahydro-β-carbolines

2. Brossi, A. In The Alkaloids; Cordell, G. A., Ed.; Academic: San Diego, New York, Berkely, Boston, London, Sydney, Tokyo, Toronto, 1993; Vol. 43, pp 119–183.

3. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

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