L-leucine stimulates glutamate dehydrogenase activity and glutamate synthesis by regulating mTORC1/SIRT4 pathway in pig liver

Author:

Wang Tongxin,Yao Weilei,He Qiongyu,Shao Yafei,Zheng Ruilong,Huang Feiruo

Funder

National Key Research and Development Program

National Natural Science Foundation of China

National Basic Research Program of China

Publisher

Elsevier BV

Subject

Animal Science and Zoology,Food Animals

Reference39 articles.

1. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine;Anthony;J Nutr,2001

2. Alanine metabolism in the perfused rat liver. Studies with (15)N;Brosnan;J Biol Chem,2001

3. Branched-chain amino acids: enzyme and substrate regulation;Brosnan;J Nutr,2006

4. Hepatic glutamate metabolism: a tale of 2 hepatocytes;Brosnan;Am J Clin Nutr,2009

5. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4;Csibi;Cell,2013

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