Interactions of myeloma cells with osteoclasts promote tumour expansion and bone degradation through activation of a complex signalling network and upregulation of cathepsin K, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA)

Author:

Hecht Monica,von Metzler Ivana,Sack Katja,Kaiser Martin,Sezer Orhan

Publisher

Elsevier BV

Subject

Cell Biology

Reference34 articles.

1. Cancer and the microenvironment: myeloma–osteoclast interactions as a model;Yaccoby;Cancer Res.,2004

2. New potential targets for treating myeloma bone disease;Roodman;Clin. Cancer Res.,2006

3. Osteoclast differentiation and activation;Boyle;Nature,2003

4. Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo;Farrugia;Cancer Res.,2003

5. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment;Giuliani;Blood,2001

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