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Direct inhibition of RAS: Quest for the Holy Grail?

  • Published:2019-02 Issue: Volume:54 Page:138-148
  • ISSN:1044-579X
  • Container-title:Seminars in Cancer Biology
  • language:en
  • Short-container-title:Seminars in Cancer Biology

Author:

Spencer-Smith Russell,O’Bryan John P.

Funder

NIH F31 Predoctoral Award

United States (US) Department of Veterans Affairs Biomedical Laboratory Research and Development Service

NIH awards

Publisher

Elsevier BV

Subject

Cancer Research

Reference115 articles.

1. An unidentified virus which causes the rapid production of tumours in mice;Harvey;Nature,1964

2. Morphologic responses to a murine erythroblastosis virus;Kirsten;J. Natl. Cancer Inst.,1967

3. Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1;Hall;Nature,1983

4. Three human transforming genes are related to the viral ras oncogenes;Shimizu;Proc. Natl. Acad. Sci. U. S. A.,1983

5. Drugging the undruggable RAS: mission possible?;Cox;Nat. Rev. Drug Discov.,2014

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