Preclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability-related effects

Author:

Witkin JM,Monn JA,Li J,Johnson B,McKinzie DL,Wang X-S,Heinz BA,Li R,Ornstein PL,Smith SC,Mitch CH,Calligaro DO,Swanson S,Allen D,Phillips K,Gilmour G

Publisher

Elsevier BV

Subject

Behavioral Neuroscience,Biological Psychiatry,Clinical Biochemistry,Pharmacology,Toxicology,Biochemistry

Reference34 articles.

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2. A role for AMPA receptors in mood disorders;Alt;Biochem. Pharmacol.,2006

3. Antidepressant effects of ketamine in depressed patients;Berman;Biol. Psychiatry,2000

4. MGS0039: A Potent and Selective Group II Metabotropic Glutamate Receptor Antagonist With Antidepressant-like Activity;Chaki,2004

5. Discovery of LY3020371, a potent and selective orthosteric antagonist of mGlu2/3 receptors;Chappell;J. Med. Chem.,2016

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