Inhaled antisense oligonucleotide therapies: Inspiration and progress

Author:

Karras James G.,Geary Richard S.,Gregory Susan A.

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Reference34 articles.

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3. Phase I trial of ISIS 104838, a 2′-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha;Sewell;J. Pharmacol. Exp. Ther.,2002

4. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2′-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer;Chi;J. Natl. Cancer Inst.,2005

5. Topigen reports positive therapeutic results from initial phase II trial studying inhaled TPI-ASM8 in patients with mild-to-moderate asthma. Phase II data validates TPI-ASM8 clinical targets and efficacy of multi-targeted antisense in the respiratory tract. Company press release, July 18, 2006

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3. The Pharmacokinetics Research of Nucleic Acid Drugs;Medicinal Chemistry of Nucleic Acids;2011-07-25

4. Therapeutic Applications of Antisense Oligonucleotides in Asthma and Allergy;Recent Patents on Inflammation & Allergy Drug Discovery;2007-11-01

5. Anti-Inflammatory Activity of Inhaled IL-4 Receptor-α Antisense Oligonucleotide in Mice;American Journal of Respiratory Cell and Molecular Biology;2007-03

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