Water-soluble HPMA copolymer–wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo

Author:

Varticovski L.,Lu Zheng-Rong,Mitchell Kahlil,de Aos Isabel,Kopeček Jindrich

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference34 articles.

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2. Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain;Serunian;J. Cell Biol.,1989

3. Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II;Lips;J. Biol. Chem.,1989

4. Using structure to define the function of phosphoinositide 3-kinase family members;Domin;FEBS Lett.,1997

5. The CSF-1 receptor associates with and activates PI 3-kinase;Varticovski;Nature,1989

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