1. Synthesis of perfluorobicyclic ethers [1]. The electrochemical fluorination of cycloalkyl-substituted carboxylic acids
2. A NEW ROUTE TO PERFLUOROBICYCLIC ETHERS. AN UNUSUAL FLUORINATION PRODUCT FROM CYCLOHEXEN-2-YL-SUBSTITUTED CARBOXYLIC ACID ESTERS
3. Fluosol-DA is known as an artificial blood (oxygen-carrying blood substitute) developed by Green Cross Co., Osaka, Japan, which is about to be used in medical practice. Its perfluorocarbon emulsion is based on the use of a mixture of perfluorodecalin (14 weight-to-volume %) and perfluorotripropylamine (6%). The latter amine is just added in order to supply a deficiency in emulsion stability of the former. Hence, in order to resolve this problem, new perfluorobicyclic compounds which contain a hetero atom (O or N) have been looked for as a ‘second eneration of blood substitute’, which may have sufficient emulsion stability yet retain the desired transpiration characteristics in itself. On this idea, Yokoyama and his co-workers at Green Cross Co. have recently suggested new perfluoroheterocyclic compounds like perfluoro(N-methyldecahydroquinoline), perfluoro(1-methyloctahydroquinolizine) and perfluoro(N-cyclohexylpyrrolidine). For recent topics about artificial blood, see for example: R. Dagai, Chem. Eng. News, 60 May 31 (1982) 31.
4. The Fluorination of Carbon Monoxide, Carbonyl Chloride, and Carbonyl Fluoride