Trabectedin as a Single-Agent Treatment of Advanced Breast Cancer After Anthracycline and Taxane Treatment: A Multicenter, Randomized, Phase II Study Comparing 2 Administration Regimens

Author:

Goldstein Lori J.,Gurtler Jayne,Del Prete Salvatore A.,Tjulandin Sergei,Semiglazov Vladimir F.,Bayever Eliel,Michiels Bart

Funder

Janssen Research & Development, LLC

PharmaMar

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference40 articles.

1. American Cancer Society. Cancer Facts & Figures 2014. Available at: http://www.cancer.org/acs/groups/content/@research/documents/webcontent/acspc-042151.pdf. Accessed June 16, 2014.

2. Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin;van Kesteren;Anticancer Drugs,2003

3. Mechanism for the catalytic activation of ecteinasacidin 743 and its subsequent alkylation of guanine N2;Moore;J Am Chem Soc,1998

4. Ecteinascidin-743: a minor groove alkylator that bends DNA towards the major groove;Zewail-Foote;J Med Chem,1999

5. DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by Ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata;Pommier;Biochemistry,1996

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