Oral dosing of rats with OM-89 results in the appearance of specific OM-89 antibodies of the IgG2a isotype: possible significance in the treatment of rheumatoid arthritis

Author:

Phipps P.A.,Moore A.R.,Gowland G.,Khanam A.,Willoughby D.A.

Publisher

Elsevier BV

Subject

Pharmacology,Immunology

Reference28 articles.

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2. Biological activity of bacterial surface components: immunogenicity and immunomodulatory properties of a bacterial extract from Escherichia coli;Bessler;Arzneim Forsch/Drug Res.,1991

3. A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic;Billingham;J. exp. Med.,1990

4. Enhancement of the humoral reponse and resistance to bacterial infection in mice by oral administration of a bacterial immunomodulator (OM-89);Bosch;Immunopharmacol. Immunotoxicol.,1988

5. Effects of two bacterial extracts, OM-89 and Broncho-Vaxom, on IL-I release and metabolic activity of a human macrophage cell line;Bottex;Int. J. Immunother.,1988

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