Long-term exposure to methotrexate induces immunophenotypic changes, decreased methotrexate uptake and increased dihydrofolate gene copy number in jurkat T cells

Author:

Hall Michael J.,Lawrence David A.,Lansiedel John C.,Walsh Anne C.,Comstock Laura L.,Kremer Joel M.

Publisher

Elsevier BV

Subject

Pharmacology,Immunology

Reference48 articles.

1. Chromosomal organization of the human dihydrofolate reductase genes: dispersion, selective amplification, and a novel form of polymorphism.

2. Bertino, J. R. and Rodenhuis, S. (1987) Methotrexate and Drug Resistance : Advances in Cancer Chemotherapy, Bladder Cancer : Future Directions for Treatment (ed. A. Yagoda) . John Wiley and Sons, New York.

3. Intronless human dihydrofolate reductase genes are derived from processed RNA molecules.

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