Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition 1 1Confocal imaging studies were performed in the Confocal Microscopy core of the University of Southern California Center for Liver Disease Research. The authors thank Dr. Carol Gregorio (University of Arizona) for her invaluable advice on actin studies and Peixin Wang for performing part of the gelatin zymography studies.