Clinical and Immunologic Responses of HLA-A3+ Breast Cancer Patients Vaccinated with the HER2/neu-Derived Peptide Vaccine, E75, in a Phase I/II Clinical Trial

Author:

Patil Ritesh,Clifton Guy T.,Holmes Jarrod P.,Amin Asna,Carmichael Mark G.,Gates Jeremy D.,Benavides Linda H.,Hueman Matthew T.,Ponniah Sathibalan,Peoples George E.

Publisher

Elsevier BV

Subject

Surgery

Reference40 articles.

1. National Cancer Institute of Canada Clinical Trials Group: HER2 and responsiveness of breast cancer to adjuvant therapy;Pritchard;N Engl J Med,2006

2. Peptide priming of cytolytic activity to HER-2 epitope 369-377 in healthy individuals;Anderson;Clin Cancer Res,2000

3. Immunization with a peptide epitope (p369-377) from HER-2/neu leads to peptide-specific cytotoxic T lymphocytes that fail to recognize HER-2/neu+ tumors;Zaks;Cancer Res,1998

4. Immunization of cancer patients with a HER-2/neu, HLA-A2 peptide p369-377, results in short-lived peptide-specific immunity;Knutson;Clin Cancer Res,2002

5. Toxicity, immunogenicity, and induction of E75-specific tumor-lytic CTLs by HER-2 peptide E75 (369-377) combined with granulocyte macrophage colony-stimulating factor in HLA-A2+ patients with metastatic breast and ovarian cancer;Murray;Clin Cancer Res,2002

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