First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors

Author:

Falchook Gerald,Infante Jeffrey,Arkenau Hendrik-Tobias,Patel Manish R.,Dean Emma,Borazanci Erkut,Brenner Andrew,Cook Natalie,Lopez Juanita,Pant Shubham,Frankel Arthur,Schmid Peter,Moore Kathleen,McCulloch William,Grimmer Katharine,O'Farrell Marie,Kemble George,Burris Howard

Publisher

Elsevier BV

Subject

General Medicine

Reference34 articles.

1. Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma;Gouw;Proc Natl Acad Sci U S A,2017

2. Fatty acid synthase regulates the chemosensitivity of breast cancer cells to cisplatin-induced apoptosis;Al-Bahlani;Apoptosis,2017

3. Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer;Corominas-Faja;Histol Histopathol,2017

4. Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer;Bauerschlag;J Transl Med,2015

5. Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival;Nguyen;Clin Oncol,2010

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