Nucleoside/nucleotide reverse transcriptase inhibitor sparing regimen with once daily integrase inhibitor plus boosted darunavir is non-inferior to standard of care in virologically-suppressed children and adolescents living with HIV – Week 48 results of the randomised SMILE Penta-17-ANRS 152 clinical trial

Author:

Compagnucci Alexandra,Chan Man K.,Saïdi Yacine,Cressey Tim R.ORCID,Bamford AlasdairORCID,Riault Yoann,Coelho Alexandra,Nolan Aoife,Chalermpantmetagul Suwalai,Morkunaite Gabija,Amuge Pauline,Musiime Victor,Violari Avy,Cotton MarkORCID,Kekitiinwa Adeodata R.,Kaudha Elizabeth,Groenewald Marisa,Liberty Afaaf A.,Kanjanavanit Suparat,Volokha Alla,Bologna Rosa,Pavia Ruz Noris,Prieto Tato Luis,Paioni Paolo,Marques Laura,Reliquet VéroniqueORCID,Niehues Tim,Welch Steven B.,Ford Deborah,Giaquinto Carlo,Gibb Diana M.,Babiker AbdelORCID,Ramos Amador Jose TomasORCID,Compagnucci A.,Saidi Y.,Riault Y.,Coelho A.,Kouakam C.,Picault L.,Ndiaye M.,Meyer L.,Cagnot C.,Circosta S.,Léger L.,Simanic S.,Arulananthan A.,Gibb D.M.,Babiker A.,Chan M.,Ford D.,Hudson F.,Harper L.,Bamford A.,Nolan A.,Widuch K.,Townsend S.,Van-Looy N.,Gao L.,Little E.,Turkova A.,Fabiane S.,Calvert J.,Blackstone J.,Scott K.,Inshaw J.,Nunn A.,Nardone A.,Bilardi D.,Cressey T.R.,Chalermpantmetagul S.,Khamduang W.,Jourdain G.,Ngo Giang Huong N.,Chinwong D.,Saenjum C.,Peongjakta R.,Sukrakanchana P.,Laomanit L.,Kaewbundit A.,Khamkon J.,Than-in-at K.,Meeboon C.,Sripaoraya W.,Krueduangkam N.,Kruenual N.,Khamjakkaew W.,Klinprung S.,Giaquinto C.,Morkunaite G.,Hirt D.,Prieto Tato L.,Niehues T.,Plonné D.,Morén C.,Noguera T.,Muñoz Fernández M.A.,Bologna R.,Arazi S.,Fedullo A.G.,Taicz M.,Vicentini E.,Moragas M.,Mangano A.,Dell’Orso M.,Gatto M.,Reliquet V.,Soria A.,Paredes E.,Chereau N.,Tching Sin M.,Flet L.,Rodallec A.,Hemon C.,Elenga N.,Terrine M.D.,Blaise N.,Augustin S.,Mespoulhe P.,Pouchain H.,Pavia-Ruz N.,Muñoz- Hernández R.,Neri-Macias A.,Jarillo-Quijada M.D.,Espinosa-Sotero C.,Marques L.,Teixeira C.,Fernandes A.,Nunes R.,Nascimento H.,Tuna J.,Padrao A.,Ferraz I.,Mendes A.C.,Correira C.,Pinheiro H.,Matos A.C.,Sampaio A.C.,Oliveira A.,Caldeira A.,Tavares M.,Reis Melo A.,Castro C.,Faria C.,Prucha C.,Ribeiro R.,Monteiro F.,Candeias M.F.,Silva Milhiero T.,Gomes Neves E.,Oliveira A.,Corte-Real R.,Morgado M.,Mendes D.,Cardão M.,Violari A.,Ramsagar N.,Liberty A.,Nyati M.,Maseko L.,Khunene M.,Mkhize S.,Essack Z.,Akoojee N.,Singh U.,Fourie Y.,Govender S.,Vadee A.,Lakha R.,Erasmus J.,Mamiane A.,Daniel T.,Bhana P.,Maduna N.,Cotton M.,Groenewald M.,Slade G.,Coetzee J.,Ganger L.,Weldon S.,Wessels M.,Hoorn L.,Pieterse S.,Makola C.,Smith K.,Isaacs M.,Cweya A.,Fry S.,Barnabas S.,Theunissen M.,Nduna N.,Smuts M.,Rojo Conejo P.,Epalza C.,Prieto Tato L.,Fernández M.,Mellado Peña M.J.,Sainz Costa T.,Escosa García L.,Gomez Salcedo P.,Fortuny Guasch C.,Noguera Julian T.,Estepa C.,Cubells M.,Sans E.,Bruno E.,Prieto L.,Mendez García P.,Murciano Cabeza A.,Coto M.,Torrent R.,Torres Arauz M.,Navarro Gómez M.,Mur A.,Guillén Martin S.,Moreno M.,Ramos Amador J.T.,Garcia I.,Kalhert C.,Wachinger T.,Wohlwend B.,Hafner S.,Dollenmaier G.,Paioni P.,Signorell R.,Boni J.,Duppenthaler A.,Mann B.,Saegesser C.,Barbani M.,Ngampiyaskul C.,Greetanukroh P.,Khannak P.,Tearsansern P.,Chamjamrat W.,Chanto N.,Thapwai T.,Thungkham K.,Puangmalai P.,Ruklao C.,Ounchanum P.,Khusuwan S.,Denjanta S.,Thaweesombat Y.,Thewsoongnoen J.,Kaewmamueng K.,Kamboua P.,Pongprapass S.,Srisuk W.,Kongponoi A.,Limplertjareanwanich J.,Kanjanavanit S.,Saewtrakool C.,Yingyong P.,Chutima D.,Junkaew R.,Chankun T.,Srirompotong U.,Sudsaard P.,Kongsuk K.,Petpranee T.,Srirojana S.,Donngernl D.,Kamkoonmongkol A.,Na Kalasin N.,Phunkhum P.,Kekitiinwa A.R.,Amuge P.,Bbuye D.,Nalubwama J.,Namanda S.,Nsibuka Kisekka M.,Kirabira A.,Lawrence L.,Agaba G.,Ahimbisibwe G.,Nalugo A.,Namuli F.,Kadhuba R.,Namuddu R.,Nabwire I.,Kiyimba L.,Baita A.,Tikabibamu J.,Nakandi L.,Kisitu G.P.,Nabukeera Barung N.,Kityo C.M.,Musiime V.,Kaudha E.,Nanduudu A.,Mujyambere E.,Labeja Ocitti S.P.,Ategeka J.,Nambi E.,Nazzinda R.,Rutebarika D.,Basiimwa R.,Mbabazi R.,Kyobutungi P.,Nabalamba M.,Nakalyango A.,Tumusiime J.,Nakabuye S.,Mwebaza J.,Oruk S.,Namusanje J.,Musiime A.,Mugarura L.,Ojok M.,Kitabalwa J.,Katemba C.,Nannungi M.,Bagirigomwa E.,Odoch D.,Rubanga E.,Mulima D.,Babu E.L.,Baliruno D.,Inyakuwal C.,Williams E.D.,Mulindwa A.,Uyungrwoth A.,Raus I.,Mostovenko O.,Stepchenkova T.,Volokha A.,Primak N.,Kenny J.,Callaghan A.,Ahmad M.,Vergnano S.,Ross M.,Manyi F.,Nayagam D.,Hawkins S.,Ball C.,Hamlyn E.,Gilmour C.,Gilmour-White S.,Doshi S.,Fuller E.,Adebayo A.,Tupper K.,Nsirim E.,Welch S.,Daglish J.,Thrasyvoulou L.,Irvine E.,Gandhi K.,Vaughn-Gordon Y.,Sibanda N.

Publisher

Elsevier BV

Subject

General Medicine

Reference26 articles.

1. PENTA guidelines for treatment of paediatric HIV-1 infection 2014: optimising health in preparation for adult life. PENTA steering committee;HIV Med,2018

2. Updated recommendations on HIV prevention, infant diagnosis, antiretroviral initiation and monitoring: march 2021,2021

3. 2019 update of the drug resistance mutations in HIV-1;Wensing;Top Antivir Med,2019

4. Human immunodeficiency virus-1 infection: developing antiretroviral drugs for treatment - guidance for industry;Food Drug Administration Center for Drugs Evaluation Research,2015

5. Dolutegravir as first- or second-line treatment for HIV-1 infection in children;Turkova;N Engl J Med,2021

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