Safety, tolerability, and immunogenicity of the Ebola Sudan chimpanzee adenovirus vector vaccine (cAd3-EBO S) in healthy Ugandan adults: a phase 1, open-label, dose-escalation clinical trial

Author:

Mwesigwa Betty,Houser Katherine V,Hofstetter Amelia R,Ortega-Villa Ana M,Naluyima Prossy,Kiweewa Francis,Nakabuye Immaculate,Yamshchikov Galina V,Andrews Charla,O'Callahan Mark,Strom Larisa,Schech Steven,Anne Eller Leigh,Sondergaard Erica L,Scott Paul T,Amare Mihret F,Modjarrad Kayvon,Wamala Amir,Tindikahwa Allan,Musingye Ezra,Nanyondo Jauhara,Gaudinski Martin R,Gordon Ingelise J,Holman LaSonji A,Saunders Jamie G,Costner Pamela J M,Mendoza Floreliz H,Happe Myra,Morgan Patricia,Plummer Sarah H,Hickman Somia P,Vazquez Sandra,Murray Tamar,Cordon Jamilet,Dulan Caitlyn N M,Hunegnaw Ruth,Basappa Manjula,Padilla Marcelino,Gajjala Suprabhath R,Swanson Phillip A,Lin Bob C,Coates Emily E,Gall Jason G,McDermott Adrian B,Koup Richard A,Mascola John R,Ploquin Aurélie,Sullivan Nancy J,Kibuuka Hannah,Ake Julie A,Ledgerwood Julie E,Namugabo Jaqueline,Beingana Claire,Mukyala Maureen G.,Wandege Joseph,Nanteza Christine,Atwijuka Brenda,Kizanye Juliet,Nassanga Gertrude,Namuli Joanita,Kityo Herbert,Ssekitoleko Mathias,Nassaka Roy,Mutebe Hilda,Kabahubya Mable,Widge Alicia T.,O'Connell Sarah E.,Amoa-Awua Obrimpong,Narpala Sandeep R.,Flach Britta,Cox Josephine,Beck Allison,Guech Mercy,Seo Ellie,Stein Judy A.

Funder

U.S. Department of Defense

U.S. Army

National Institutes of Health

Publisher

Elsevier BV

Subject

Infectious Diseases

Reference25 articles.

1. Ebolavirus and other filoviruses;Takada,2022

2. Filoviridae;Kuhn,2021

3. Ebola virus disease;Jacob;Nat Rev Dis Primers,2020

4. Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses;Jones;Nat Med,2005

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