Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial

Author:

Kim Paul,Sanchez Ana M,Penke Taylor J R,Tuson Hannah H,Kime James C,McKee Robert W,Slone William L,Conley Nicholas R,McMillan Lana J,Prybol Cameron J,Garofolo Paul M

Funder

U.S. Department of Health and Human Services

BARDA

Publisher

Elsevier BV

Reference24 articles.

1. Bacteriophage prehistory: is or is not Hankin, 1896, a phage reference?;Abedon;Bacteriophage,2011

2. Sur un microbe invisible antagoniste des bacilles dysentériques;D'Herelle;CR Acad Sci Paris,1917

3. Regulations of phage therapy across the world;Yang;Front Microbiol,2023

4. Bacteriophage therapy: clinical trials and regulatory hurdles;Furfaro;Front Cell Infect Microbiol,2018

5. Magistral phage preparations: is this the model for everyone?;Pirnay;Clin Infect Dis,2023

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