Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein
Author:
Funder
University of Kent
Wellcome Trust
Diamond Light Source
Cancer Research UK
Publisher
Elsevier BV
Subject
Molecular Biology,Structural Biology
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2. Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis;Bao;Structure,2011
3. Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1;Bennett;Biochem. Biophys. Res. Commun.,2008
4. Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint;Bigot;Elife,2019
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