An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes-Reference-Cited by-同舟云学术

An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes

Published:2018-04 Issue:4 Volume:26 Page:533-544.e3
ISSN:0969-2126
Container-title:Structure
language:en
Short-container-title:Structure

Author:

Cho Lily T.-Y.,Alexandrou Aristos J.,Torella Rubben,Knafels John,Hobbs Jake,Taylor Toni,Loucif Alex,Konopacka Agnieszka,Bell Sigourney,Stevens Edward B.,Pandit Jay,Horst Reto,Withka Jane M.,Pryde David C.,Liu Shenping,Young Gareth T.^ORCID

Funder

Pfizer R&D

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference28 articles.

1. KCa channels as therapeutic targets in episodic ataxia type-2;Alvina;J. Neurosci.,2010

2. In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant;Anderson;Eur. J. Pharmacol.,2006

3. Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits;Blank;Nat. Neurosci.,2003

4. Structural determinants for the selectivity of the positive KCa3.1 gating modulator 5-methylnaphtho[2,1-d]oxazol-2-amine (SKA-121);Brown;Mol. Pharmacol.,2017

5. Modulation of recombinant and native neuronal SK channels by the neuroprotective drug riluzole;Cao;Eur. J. Pharmacol.,2002

Cited by 28 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. TRPC1: The housekeeper of the hippocampus;Cell Calcium;2024-11

2. Effects of the novel acaricide acynonapyr on the calcium-activated potassium channel;Pesticide Biochemistry and Physiology;2024-09

3. Unsupervised evolution of protein and antibody complexes with a structure-informed language model;Science;2024-07-05

4. Know your molecule: pharmacological characterization of drug candidates to enhance efficacy and reduce late-stage attrition;Nature Reviews Drug Discovery;2024-06-18

5. Identification of Riluzole derivatives as novel calmodulin inhibitors with neuroprotective activity by a joint synthesis, biosensor, and computational guided strategy;Biomedicine & Pharmacotherapy;2024-05