Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-tumoral Drug PALA

Author:

Ruiz-Ramos Alba,Velázquez-Campoy Adrián,Grande-García Araceli,Moreno-Morcillo María,Ramón-Maiques Santiago

Funder

Spanish Ministry of Economy and Competitiveness

CNIO Intramural Program

Marie Curie/WHRI-Academy

BioStruct-X project

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference54 articles.

1. Carbamoyl phosphate synthetase (glutamine-hydrolyzing): increased activity in cancer cells;Aoki;Science,1981

2. Assessment of the allosteric mechanism of aspartate transcarbamoylase based on the crystalline structure of the unregulated catalytic subunit;Beernink;Proc. Natl. Acad. Sci. USA,1999

3. Molecular size and feedback-regulation characteristics of bacterial aspartate transcarbamylases;Bethell;Arch. Biochem. Biophys.,1969

4. Purification and properties of Bacillus subtilis aspartate transcarbamylase;Brabson;J. Biol. Chem.,1975

5. The shape of CAD;Carrey,1995

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