A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate-Reference-Cited by-同舟云学术

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A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate

Published:2008-10 Issue:10 Volume:16 Page:1588-1597
ISSN:0969-2126
Container-title:Structure
language:en
Short-container-title:Structure

Author:

Zuniga Jorge E.,Schmidt James J.,Fenn Timothy,Burnett James C.,Araç Demet,Gussio Rick,Stafford Robert G.,Badie Shirin S.,Bavari Sina,Brunger Axel T.

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference27 articles.

1. PHENIX: building new software for automated crystallographic structure determination;Adams;Acta Crystallogr. D Biol. Crystallogr.,2002

2. Structural analysis of botulinum neurotoxin type E catalytic domain and its mutant Glu212→Gln reveals the pivotal role of the Glu212 carboxylate in the catalytic pathway;Agarwal;Biochemistry,2004

3. Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization;Binz;Biochemistry,2002

4. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25;Blasi;Nature,1993

5. Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin;Blasi;EMBO J.,1993

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