Modelling of bioprocess non-linear fluorescence data for at-line prediction of etanercept based on artificial neural networks optimized by response surface methodology

Author:

Chiappini Fabricio A.,Teglia Carla M.,Forno Ángela G.,Goicoechea Héctor C.

Funder

PLS

CONICET

ANPCyT

Publisher

Elsevier BV

Subject

Analytical Chemistry

Reference32 articles.

1. Manufacturing history of etanercept (Enbrel(®)): consistency of product quality through major process revisions;Hassett;mAbs,2018

2. Multivariate PAT solutions for biopharmaceutical cultivation: current progress and limitations;Mercier;Trends Biotechnol.,2014

3. Multivariate data analysis as a PAT tool for early bioprocess development data;Mercier;J. Biotechnol.,2013

4. A.P. Teixeira, R. Oliveira, P.M. Alves, M.J.T. Carrondo, Advances in On-Line Monitoring and Control of Mammalian Cell Cultures: Supporting the PAT Initiative.

5. A Review of Spectroscopic Methods and Their Applicability for High-Throughput Characterization of Mammalian Cell Cultures in Automated Cell Culture Systems;Musmann,2016

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