Enantioselective HPLC-DAD method for the determination of etodolac enantiomers in tablets, human plasma and application to comparative pharmacokinetic study of both enantiomers after a single oral dose to twelve healthy volunteers

Author:

Hewala Ismail I.,Moneeb Marwa S.,Elmongy Hatem A.,Wahbi Abdel-Aziz M.

Publisher

Elsevier BV

Subject

Analytical Chemistry

Reference44 articles.

1. Committee for Proprietary Medical Products (CPMP), Working Parties on Quality, Safety and Efficacy of Medicinal Products, Note for Guidance: Investigation of chiral active substances (III/3501/91), Brussells: CPMP, 1993.

2. Enantioselective Pharmacokinetics of Etodolac in the Rat: Tissue Distribution, Tissue Binding, and In Vitro Metabolism

3. Stereoselectivity of ibuprofen metabolism and pharmacokinetics following the administration of the racemate to healthy volunteers

4. The British Pharmacopoeia, Her Mayesty׳s Stationary Office, London, UK, 2014.

5. Modern Pharmacology with Clinical Applications,2004

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