Irreversible binding with biological macromolecules and effects in bacterial mutagenicity tests of the radical cation of promethazine and photoactivated promethazine. Comparison with chlorpromazine

Author:

de Mol Nicolaas J.,Becht Anja B.C.,Koenen Jac,Lodder Gerrit

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference17 articles.

1. On the mechanism of action of chlorpromazine;Karreman;Science,1959

2. Side-chain effects on phenothiazine cation radical reactions;Sackett;J. Med. Chem.,1981

3. Mechanisms of photosensitization by phenothiazine derivatives;Saucin;Arch. Int. Phys. Biochim.,1979

4. Degradation products of the promethazine radical cation;de Mol;Pharm. Weekblad Sci. Ed.,1985

5. Induction of repairable DNA damage in Escherichia coli and interaction with DNA in vitro by the radical cation of chlorpromazine;de Mol;Chem.-Biol. Interact.,1983

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