Stereo-selectivity and regio-selectivity in the metabolism of 7,8-dihydrobenzo[a]pyrene by cytochrome P450, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats

Author:

Adams James D.,Yagi Haruhiko,Levin Wayne,Jerina Donald M.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference41 articles.

1. Oxidation at carbon;Jerina,1976

2. Stereoselective metabolic activation of polycyclic aromatic hydrocarbons;Jerina,1979

3. Absolute stereo-chemistry of the highly mutagenic 7,8-diol 9,10-epoxides derived from the potent carcinogen trans-7,8-dihydroxy-7-dihydrobenzo[a]pyrene;Yagi;J. Am. Chem. Soc.,1977

4. Metabolism of benzo[a]pyrene VI stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7-dihydrodiol to diol epoxides;Thakker;Chem.-Biol. Interact.,1977

5. Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of the (+)-7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene;Buening,1978

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