Binding of the carcinogen 2-acetamidophenanthrene to rat liver nucleic acids: Lack of correlation with carcinogenic activity, and failure of the hydroxamic acid ester model for in vivo activation

Author:

Scribner J.D.,Koponen Gertrud

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference24 articles.

1. The carcinogenicity of compounds related to 2-acetylaminofluorene. II. Variations in the bridges and the 2-substituent;Miller;Cancer Res.,1955

2. The metabolic activation of carcinogenic aromatic amines and amides;Miller;Prog. Exp. Tumor Res.,1969

3. Tumor initiation by N-acetoxy derivatives of piperidine and N-arylacetamides;Scribner;J. Nat. Cancer Inst.,1975

4. Nucleophilic substitution on carcinogenic N-acetoxy-N-arylacetamides;Scribner;Cancer Res.,1970

5. Reactions of esters of N-hydroxy-2-acetamidophenanthrene with cellular nucleophiles and the formation of free radicals upon decomposition of N-acetoxy-N-arylacetamides;Scribner;Cancer Res.,1973

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