Alteration of urinary levels of the carcinogen, N-hydroxy-2-naphthylamine, and its N-glucuronide in the rat by control of urinary pH, inhibition of metabolic sulfation, and changes in biliary excretion

Author:

Kadlubar F.F.,Unruh L.E.,Flammang T.J.,Sparks D.,Mitchum R.K.,Mulder G.J.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference67 articles.

1. Isolation of the glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl from dog urine and its mutagenic activity;Radomski;Cancer Res.,1977

2. N-Glucuronidation of N-hydroxy aromatic amines: a mechanism for their transport and bladder-specific carcinogenicity;Poupko;Tox. Appl. Pharmacol.,1979

3. Hepatic microsomal N-glucuronidation and nucleic acid-binding of N-hydroxy arylamines in relation to urinary bladder carcinogenesis;Kadlubar;Cancer Res.,1977

4. The primary aromatic amines, their biological properties, and structure-activity relationships;Radomski;Ann. Rev. Pharmacol. Toxicol.,1979

5. N-Oxidation of certain aromatic amines, acetamides, and nitro compounds by monkeys and dogs;Radomski;J. Natl. Cancer Inst.,1973

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