Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY): a randomised, placebo-controlled, phase 2 trial

Author:

Cadavid Diego,Mellion Michelle,Hupperts Raymond,Edwards Keith R,Calabresi Peter A,Drulović Jelena,Giovannoni Gavin,Hartung Hans-Peter,Arnold Douglas L,Fisher Elizabeth,Rudick Richard,Mi Sha,Chai Yi,Li Jie,Zhang Yiwei,Cheng Wenting,Xu Lei,Zhu Bing,Green Susan M,Chang Ih,Deykin Aaron,Sheikh Sarah I,Agüera Morales Eduardo,Al Khedr Abdullatif,Ampapa Radek,Arroyo Rafael,Belkin Martin,Bonek Robert,Boyko Alexey,Capra Ruggero,Centonze Diego,Clavelou Pierre,Debouverie Marc,Drulovic Jelena,Edwards Keith,Evangelou Nikos,Evdoshenko Evgeniy,Fernández Oscar,Fernández Sánchez Victoria,Freedman Mark,Freedman Steven,Fryze Waldemar,Garcia-Merino Antonio,Gavric-Kezic Mira,Ghezzi Angel,Gout Olivier,Grimaldi Luigi,Hendin Barry,Hertmanowska Hanka,Hintzen Rogier,Hradilek Pavel,Hupperts Raymond,Ilkowski Jan,Ivashinenkova Evelina,Izquierdo Guillermo,Jacques Francois,Jakab Gabor,Khabirov Farit,Klodowska-Duda Gabriela,Komoly Samuel,Kostic Smiljana,Kovarova Ivana,Kremenchuzky Marcelo,Laganke Christopher,LaPierre Yves,Maciejowski Maciej,Maison Francois Grand,Marfia Girolama Alessandra,Martínez Yélamos Sergio,Meluzinova Eva,Montalban Xavier,Murray Ronald,Naismith Robert,Newsome Scott,Nguyen Viet,Oreja Delia,Pardo Gabriel,Pasechnik Elena,Patti Francesco,Potemkowski Andrzej,Prokopenko Semen,Qian Peiqing,Rodríguez-Antigüedad Alfredo,Rossman Howard,Rozsa Csilla,Sánchez López Fernando,Selmaj Krzysztof,Silber Eli,Stepien Adam,Stepniewska Anna,Swiat Maciej,Toncev Gordana,Tourbah Ayman,Trushnikova Tatyana,Uccelli Antonio,Vachova Marta,Valis Martin,Vecsei Laszlo,Wiertlewski Sandrine,Zaffaroni Mauro,Zielinski Tomasz

Publisher

Elsevier BV

Subject

Clinical Neurology

Reference31 articles.

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2. Multiple sclerosis: immunopathology and treatment update;Dargahi;Brain Sci,2017

3. Pushing forward: remyelination as the new frontier in CNS diseases;Kremer;Trends Neurosci,2016

4. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex;Mi;Nat Neurosci,2004

5. NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination;Lee;J Neurosci,2007

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